Epilepsy Research Laboratory
Department of Neurological Surgery
University of California, Irvine
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Developmental regulation of AQP4 in mouse hippocampus. Low-power views of coronal mouse brain sections in P9 vs. 3-week-old vs. 6-week-old mice. While AQP4 immunoreactivity is greatest in the CA1 SLM at P9, AQP4 immunoreactivity at 3 and 6 weeks is dramatically upregulated, particularly in CA1 SLM but also more diffusely throughout the hippocampus. Blood vessels are labeled well at all developmental stages. No specific immunoreactivity is present in sections from adult AQP4-/- mice (right). Nissl counterstains are shown in the bottom panels for each image. Scale bar, 300 µm.
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